Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

Recruiting now · Early Phase 1

Conditions studied: Cystic Fibrosis

In brief

In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this population.

Key facts

Study ID

NCT06163482

Run by

University of Cincinnati

People needed

61

Starts

2023-03-28

Expected to finish

2026-12-30

Last updated by the study team

2026-03-23

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosed with cystic fibrosis
• Aged 18 to 45 years
• Males and females of any race and ethnicity
• Receiving highly effective CFTR modular therapy

You may not qualify if…

• Transplant recipient
• Acute lung function decline or exacerbation within the last 3 months
• Use of systemic glucocorticoids
• Pregnancy
• Known liver disease that would be expected to significantly impact metabolic variable as interpreted by a study doctor
• The presence of any other disease or condition, as interpreted by any one of the study doctors, that would be expected to confound the responses to liquid mixed meal or make participation in the study dangerous to the individual
• People who are cognitively impaired
• People who do not speak English
• For CFRD patients, a daily insulin requirement that exceeds 0.8 U/kg/day
• Any prior history of diabetic ketoacidosis.

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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