Individualized Physical Activity or Patients With Non Functioning Pituitary Adenoma

Recruiting now · Not applicable

Conditions studied: Non-functioning Pituitary Adenoma

In brief

The goal of this clinical trial is to learn about physical activity's effect on health in people who have had surgery of a non-functioning pituitary adenoma. The main questions it aims to answer are: * Do physical activity increase quality of life? * Do physical activity increase general health, cardiovascular fitness, self-efficacy and muscle strength and reduce fatigue and cardiovascular risk profile? Participants will at the start of the the study, at 6 months follow up and 12 months follow up: * Fill out health surveys * Perform a cycling test, hand strength test, chair stand test and wear and accelerometer for a week * Undergo a dual energy X-ray absorptiometry to measure muscle and fat mass * Leave blood samples Researchers will compare those who are randomized to the intervention and see a physiotherapist to get an individualized and person-centred prescription of physical activity plan and those who are randomized not to be in the intervention to see if physical activity increases quality of life and general health.¨.

Key facts

Study ID: NCT06163261
Run by: Vastra Gotaland Region
People needed: 120
Starts: 2024-02-27
Expected to finish: 2027-12-31
Last updated by the study team: 2025-09-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients with clinically significant non-functioning pituitary adenoma treated with surgery during the last ten years
Stable hormone replacement therapy ≥ 6 months
Ability to communicate in Swedish.

You may not qualify if…

Patients with any other pituitary tumors than non-functioning pituitary adenoma
Patients who possibly need tumor intervention, either with surgery or radiotherapy, within one year
Other diseases or co-morbidities that may have significant impact on the outcome variables, including:
Ongoing substance abuse and/or untreated psychiatric disorder, including psychoses and bipolar disease (except treatment with SSRI (Selective Serotonin Reuptake Inhibitor) and or SNRI (Serotonin-Norepinephrine Reuptake Inhibitor) for mild/moderate depression and/or anxiety which is allowed).
Medical therapy with opioids, sedatives or hypnotics (besides treatment with zopiclone and zolpidem which are allowed).
Current or previous history of neurological diseases with impaired mobility.
High alcohol consumption (more than 14 alcohol units per week)
Ongoing treatment for cancer.
Uncontrolled hypertension or presence of clinically significant cardiac disease
Severe respiratory insufficiency.
Severely impaired hepatic function (ALT (Alanine Aminotransferase) and/or AST (Aspartate Aminotransferase) concentrations two times above the upper limit of normal).
Severely impaired renal function (Glomerular filtration rate <45 ml/min).
Untreated hypo- or hyperthyroidism
Pregnancy or breast feeding.

Where it is running

Sahlgrenska Univesity Hospital — Gothenburg, Västra Götaland County, Sweden (enrolling)

Full record on ClinicalTrials.gov

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