Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants

Recruiting now

Conditions studied: Bronchiolitis

In brief

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.

Key facts

Study ID

NCT06161285

Run by

Assistance Publique - Hôpitaux de Paris

People needed

120

Starts

2024-12-06

Expected to finish

2026-04-01

Last updated by the study team

2025-02-26

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants <12 months
• With bronchiolitis during RSV epidemic season
• No chronic illness
• No bronchiolitis medical history
• Signed consent from parents or legal guardians

You may not qualify if…

• Chronic respiratory illness
• Medical history of bronchiolitis or newborn asthma
• Treatment with immunosuppressants
• Patient with no social security affiliation

Where it is running

• APHP, Antoine Béclère Hospital — Clamart, France (enrolling)
• AP-HP,Raymond Poincaré Hospital — Garches, France (enrolling)
• Réanimation médico-chirurgicale Necker — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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