D-SOLVE Cohorts (Cohort a and B)

Recruiting now

Conditions studied: HDV, HDV Infection, Chronic Liver Disease

In brief

Hepatitis D is by far the most severe form of chronic viral hepatitis, frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection Hepatitis D is caused by co-infection with hepatitis B virus (HBV) and hepatitis D virus (HDV). This multicenter cohort should enable a comprehensive and unbiased biomarker screening of well-defined HDV-infected patients, followed by mechanistic studies to determine the functional role of distinct molecules. Patient surveillance strategies and antiviral treatment approaches could be personalized which should reduce clinical and social disease burden, improve quality of life and save direct and indirect costs caused by HDV infection.

Key facts

Study ID

NCT06160635

Run by

Hannover Medical School

People needed

750

Starts

2023-02-22

Expected to finish

2026-09-30

Last updated by the study team

2025-03-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Anti-HDV positive
• ≥18 years old
• Sex: m/f/d
• Informed consent for prospective procedures

You may not qualify if…

• Anti-HDV negative

Where it is running

• Hannover Medical School, Department of Gastroenterology, Hepatology, Infectious Disease and Endocrinology — Hanover, Germany (enrolling)
• Institutul de Boli Infectioase "Prof. Dr. Matei Bals" — Bucharest, Romania (enrolling)
• Karolinska University Hospital and Karolinska Institutet — Stockholm, Sweden (enrolling)
• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (University of Milan) — Milan, Italy

Full record on ClinicalTrials.gov

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