A Study To Evaluate The Safety Of CMTX-101 In People With Cystic Fibrosis

Completed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Persistent Infection, Cystic Fibrosis

In brief

CMTX-101 is a bacterial biofilm disrupting monoclonal antibody being developed as an adjunctive therapy to standard of care antibiotics. The goal of this clinical trial is to assess the safety and tolerability of CMTX-101 in people with cystic fibrosis (pwCF). The main questions the study aims to answer are: * Are single doses of CMTX-101 IV infusion safe and tolerated * What is the pharmacokinetic (PK) profile of single doses of CMTX-101 * Do single doses of CMTX-101 induce development of anti-drug antibodies (ADA) and neutralizing antibodies (Nabs)

Key facts

Study ID

NCT06159725

Run by

Clarametyx Biosciences, Inc.

People needed

43

Starts

2024-06-24

Expected to finish

2025-11-14

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ≥18 years of age at the time of screening.
• If enrolled in the CFF Patient Registry, must provide registry information.
• Confirmed CF diagnosis based on current CF Foundation (CFF)-sponsored guidelines.
• For participants on modulator therapy, they must be on a stable dose of modulator therapy for at least 3 months.
• Willing and capable of providing induced sputum for evaluation at defined study timepoints.
• Positive P. aeruginosa growth of ≥104 CFU/gram from a sample of induced sputum at the screening visit.
• FEV1 ≥50% (Part1) or ≥35% (Part 2) of predicted normal value at screening.
• Currently receiving inhaled antibiotic therapy, either tobramycin or aztreonam alone, or as part of CAT. At least one 28-day cycle completed within 8 weeks prior to screening visit.
• Women of childbearing potential (WOCBP) must have a negative serum beta-human chorionic gonadotropin test during screening and agree to use an effective method of contraception for the duration of the study and for 4 months after the last infusion of study drug. A female participant is considered of childbearing potential unless postmenopausal or surgically sterilized and at least 3 months has passed since sterilization procedure. Female surgical sterilization procedures include tubal ligation, bilateral salpingectomy, hysterectomy, or bilateral oophorectomy. A female participant is considered postmenopausal if she has had spontaneous amenorrhea for at least 2 years with an appropriate clinical profile (e.g., age appropriate, history of vasomotor symptoms).
• Effective methods of contraception include (a) abstinence, (b) partner vasectomy, (c) intrauterine devices, (d) hormonal implants (such as Implanon), or (e) other hormonal methods (birth control pills, injections, patches, vaginal rings).
• Male participants with a female partner must use a medically accepted contraceptive regimen during his participation in the study and for 4 months after study drug infusion.
• Acceptable methods of contraception for male participants include condoms with spermicide, surgical sterilization of the participant (i.e., vasectomy) at least 26 weeks before screening, or sexual abstinence (i.e., refraining from heterosexual intercourse) if that is the preferred and usual lifestyle of the participant.
• Males with infertility documentation are not required to use contraception.
• Male participants must agree to abstain from sperm donation through 4 months after study drug administration.
• Capable of providing informed consent.
• Capable and willing to complete all study visits and perform all procedures required by the protocol.

You may not qualify if…

• Body mass index (BMI) <14 at screening and baseline.
• Has a known history or evidence of human immunodeficiency virus (HIV) infection or chronic hepatitis B screening.
• Tests positive for hepatitis C virus (HCV) RNA at screening.
• Pulmonary exacerbation within 28 days of baseline.
• Requirement for continuous (24 hour/day) oxygen supplementation; periodic use is permitted.
• Participation in smoking or vaping activity in the last 6 months.
• History of, or planned, organ transplantation.
• Elevated liver function tests obtained at screening.
• ALT >5 × ULN or AST >5 × ULN, or
• Total bilirubin >3 × ULN or Total bilirubin >1.5 × ULN combined with either ALT >3 × ULN or AST >3 × ULN. ULN reflects local laboratory ranges.
• Greater than 5 ml of hemoptysis on one occasion or >30 mL of hemoptysis in a 24-hour period within 28 days of baseline.
• Infection with other more pathogenic organisms such as Mycobacterium abscessus or Burkholderia spp., where the investigator feels that the participant either is not or will not remain clinically stable throughout the duration of the study.
• Acute clinical illness requiring a new (oral, parenteral, or inhaled) antibiotic(s) ≤30 days prior to the baseline visit. Does not include chronic suppressive medications or cyclic dosing medications such as inhaled antibiotics.
• Women who are pregnant, planning to become pregnant during the study period or for 4 months following last infusion of study drug, or breastfeeding.
• Active treatment of any mycobacterial or fungal organisms ≤30 days prior to baseline visit. Chronic treatment for suppression of fungal populations is allowable.
• Anticipated need to change chronic (either inhaled or oral) antibiotic regimens during the study period. Participants must agree to maintain their current chronic antibiotic regimen from the screening visit for the duration of the follow-up period (approximately 30 days).
• Known allergy to any component of the study drug.
• Participant with an estimated glomerular filtration rate <60 mL/min/1.73 m2.
• Any significant finding that, in the opinion of the investigator, would make it unsafe for the participant to participate in this study or would not be in the best interest of the participant.
• Enrolled in an interventional clinical study within ≤60 days of the baseline visit, or participating in a clinical study while enrolled in this clinical study (inclusive of vaccine studies).
• Currently or previously enrolled in this study.

Where it is running

• University of Alabama, Birmingham — Birmingham, Alabama, United States
• Stanford University — Palo Alto, California, United States
• University of California, San Francisco — San Franciso, California, United States
• National Jewish Health — Denver, Colorado, United States
• Central Florida Pulmonary Group, PA — Orlando, Florida, United States
• St Luke's Sleep Medicine and Research Center — Boise, Idaho, United States
• Cystic Fibrosis Institute — Northfield, Illinois, United States
• University of Kansas — Kansas City, Kansas, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• New York Medical College — Hawthorne, New York, United States
• Lenox Hill Hospital — New York, New York, United States
• Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States
• PennState Health — Hershey, Pennsylvania, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Vanderbilt University — Nashville, Tennessee, United States
• University of Utah — Salt Lake City, Utah, United States
• Virginia Commonwealth University — Richmond, Virginia, United States
• Seattle Children's Hospital — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.