Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program for PASC Program to Improve Functioning of Persons Suffering From Post-COVID-19 Syndrome: A Randomized Controlled Trial

Completed · Not applicable

Conditions studied: Post-Acute COVID-19, Post-Acute COVID-19 Syndrome, Post-Acute COVID-19 Infection, Long COVID, Long Covid19, Dyspnea, Orthostasis, Cognitive Impairment

In brief

About 10-20% of persons who contract SARS CoV-2 will experience persistent post-acute sequelae of SARSCoV-2 infection (referred here as PASC). While treatments offered at emerging outpatient COVID recovery clinics are being informed by previous similar diseases, the need is great for a better understanding of the unique needs of this growing population and for tested, efficacious rehabilitation programs to address them. We provide both here.The targeted six-week program will be comprised of a core set of therapies, including individually titrated stretching and flexibility, strengthening of accessory breathing muscles and diaphragm, resistance and aerobic conditioning, and vestibular rehabilitation, supplemented by neuropsychological and cognitive remediation tailored to patients' needs.

Key facts

Study ID

NCT06156202

Run by

University of Pennsylvania

People needed

125

Starts

2023-11-15

Expected to finish

2025-11-30

Last updated by the study team

2026-01-20

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years if age or older
• English or Spanish speaking
• Previously tested positive for COVID
• Still having symptoms not explained by any other etiologies
• Cognitive impairment
• Fatigue

You may not qualify if…

• Participation in another clinical trial
• Score greater than 12 on the fatigue scale
• Score greater than 30 on the memory/thinking scale
• Severe cognitive impairment (i.e. Alzheimer's, Dementia)
• Mental or physical inability to participate in the program

Where it is running

• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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