ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study

Recruiting now · Not applicable

Conditions studied: Fluid Overload, Dialysis; Complications

In brief

Patients performing chronic hemodialysis (HD) retain more or less water between dialyses. The water is removed by ultrafiltration and usually during the cleansing of waste products - the HD. The length of HD is usually the same as the time of fluid removal while sometimes this may differ. There is no clear guideline. In previous research the investigator noted that the heart releases more NT-pro-BNP during HD in numerous of the patients. The present study aims to clarify if the speed of fluid removal during HD is a factor that may alter the release of cardiac markers during HD. If so the recommendations for the prescription of HD can be updated.

Key facts

Study ID

NCT06153888

Run by

Umeå University

People needed

40

Starts

2023-03-20

Expected to finish

2026-04-30

Last updated by the study team

2024-12-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult HD patients with an intra-dialytic weight gain (IDWG) ≥2.5% of target weight over the long interval (3 days) prior to inclusion.
• Patients need to be able to understand the study information
• Patients need to be able to give consent.

You may not qualify if…

• Active systemic inflammatory state such as extensive malignancy or acute septic infection.
• Uncontrolled hyperphosphatemia decided by the local routine of the physician (due to somewhat decreased efficacy of the low flux filter to eliminate phosphate)

Where it is running

• Region Vasterbotten, Norrlands Universitetssjukhus, Dialysen — Umeå, Sweden (enrolling)

Full record on ClinicalTrials.gov

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