HRD Tests for Ovarian cancER
Recruiting now · Phase 2
Conditions studied: Ovarian Cancer
In brief
The study concerns patients with Invasive epithelial ovarian cancer, primary Fallopian tube carcinoma, ovarian-type peritoneal carcinoma, and with an indication of a first-line platinum-based chemotherapy. To determine HRD status, 2 separate tests will be performed in the study: 1. Giscar assay : developed by the sponsor 2. myChoice assay If one or two tests identifies a HRD status : a PARP inhibitor treatment may be initiated according to current recommendations
Key facts
- Study ID
- NCT06152731
- Run by
- Centre Francois Baclesse
- People needed
- 88
- Starts
- 2024-02-15
- Expected to finish
- 2031-06-01
- Last updated by the study team
- 2025-09-17
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Patient aged 18-year or more
- Histologically documented high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer
- Newly diagnosed advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV) ovarian carcinoma, candidate to a first line platinum-based chemotherapy
- Tumor tissue must be available for HRD analyses (FFPE tissue block) and
- Collected if possible during the initial surgery or the initial biopsy (before chemotherapy)
- With sufficient tumour surface area (> 25 mm²), with a final cellularity of at least 20%
- Patient affiliated to an appropriate social security system
- Patient signed consent form before any trial related activities
You may not qualify if…
- Recurrent high grade serous epithelial ovarian cancer, fallopian tube or peritoneum cancer
- Non epithelial or borderline ovarian cancer
- Other tumor, for which the treatment may interfere with the ovarian cancer treatment and/or that may have a major impact on prognosis
- Exclusive palliative setting
- Patient deprived of liberty or placed under the authority of a tutor
Where it is running
- Centre Francois Baclesse — Caen, France (enrolling)
- Centre Oscar Lambret — Lille, France (enrolling)
- Centre Henri Becquerel — Rouen, France (enrolling)
- Chu Amiens — Amiens, France
Full record on ClinicalTrials.gov
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