French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis
Recruiting now · Not applicable
Conditions studied: Amyotrophic Lateral Sclerosis
In brief
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease. However, the pathophysiological mechanisms behind weight loss remain unknown. Identifying these mechanisms could make it possible to propose an effective therapeutic strategy against weight loss for ALS patients, which could improve their survival and quality of life. In this context, the investigators are proposing an innovative multidisciplinary project aimed at structuring a large Franco-German cohort to identify the markers associated with weight loss in ALS. Participants will undergo high quality standard care for ALS patients. In addition, participants will be asked to respond different questionnaires and blood samples will be taken for analysis to identify biological markers.
Key facts
- Study ID
- NCT06147843
- Run by
- University Hospital, Limoges
- People needed
- 1000
- Starts
- 2024-09-17
- Expected to finish
- 2029-09-30
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Incident cases included at the time of diagnosis with a definite, probable, probable laboratory-supported, or possible ALS according to El Escorial revised criteria and Gold Coast criteria for early diagnosis.
- Incident ALS cases identified and followed-up in the participant ALS \& Other Motor Neuron Diseases Referral Centres: seven in France and two in Germany.
- Patients who signed the informed consent form.
- Adults aged >18 years old
You may not qualify if…
- Inability to understand the requirements of the protocol.
- Cognitive inability to sign and comprehend the informed consent form.
- Patients who will not accept Riluzole therapy during their follow-up.
Where it is running
- CHU de Lille — Lille, France (enrolling)
- Limoges University Hospital — Limoges, France (enrolling)
- Hôpital de la Timone — Marseille, France (enrolling)
- Hôpital Gui Chauliac — Montpellier, France (enrolling)
- CHU de Nice — Nice, France (enrolling)
- Hôpital de la Pitié Salpêtrière — Paris, France (enrolling)
- CHU de Tours — Tours, France (enrolling)
- Klinik für Medizinische Hochschule Hannover Carl-Neuberg-Str. 1 — Hanover, Allemagne, Germany
- Klinik für Neurologie, Universitäts- und Rehabilitationskliniken Ulm (RKU — Ulm, Allemagne, Germany
Full record on ClinicalTrials.gov
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