A Pilot Study for Pupillary Assessment to Predict CAR-T Related Neurotoxicity

Recruiting now

Conditions studied: Neurotoxicity

In brief

To learn about the relationship between changes in pupil size and reactivity and the start of neurological side effects in patients after receiving CAR-T cell therapy.

Key facts

Study ID

NCT06144151

Run by

M.D. Anderson Cancer Center

People needed

100

Starts

2024-02-08

Expected to finish

2027-04-01

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• To be considered eligible for study participation, patient will satisfy all relevant inclusion criteria and none of the exclusion criteria.
• Inclusion Criteria:
• Ages Eligible for Study: 18 Years and above (Adult, Older Adult)
• Sexes Eligible for Study: All
• Patient with histologically proven DLBCL, PMBCL or tFL, or follicular Lymphoma receiving axi-cel CAR-T cell therapy in the inpatient setting at MD Anderson Cancer Center
• Ability to understand and the willingness to sign a written informed consent document.

You may not qualify if…

• Patients who have already been administered CAR-T cell therapy.
• The patient who is unwilling or unable to comply with the requirements of the study including being able to be assessed with pupillometer
• Patient has a condition which places him at an unacceptable risk as determined by the investigator

Where it is running

• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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