Ultrasound-assisted, Catheter-directed Thrombolysis for Acute Intermediate-high-risk Pulmonary Embolism
Recruiting now
Conditions studied: Pulmonary Embolism
In brief
The purpose of this retrospective and prospective multicenter study is to evaluate the incidence of pulmonary hypertension (PH) within 6 months from ultrasound-assisted, Catheter-directed Thrombolysis for acute intermediate- high-risk Pulmonary Embolism
Key facts
- Study ID
- NCT06143969
- Run by
- Niguarda Hospital
- People needed
- 180
- Starts
- 2022-11-28
- Expected to finish
- 2027-03-31
- Last updated by the study team
- 2026-04-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients admitted with acute intermediate-high risk PE, defined according to ESC guidelines
- Symptoms onset within previous 14 days associated or not with deep venous thrombosis
- Confirmation of the PE by contrast-enhanced computed tomography of the chest with embolus located in at least one main or proximal lower lobe pulmonary artery
- Echocardiographic parameters of RV disfunction
- Patients with high-risk PE or hemodynamic deterioration on anticoagulation, who have absolute contraindications (high bleeding risk) to systemic thrombolysis and symptoms onset during the last 14 days. Patients with surgery-related embolic complications are also included (within 48 hours).
You may not qualify if…
- Age < 18 years old
- Patients unable to give informed consent
- Pregnancy
- Patients received fibrinolytic drugs in the preceding 4 days
- Bleeding diathesis
- Known bleeding disorder
- Low platelet count (< 100.000/uL
- Gastrointestinal bleeding in the preceding 3 month
- Any ongoing known presence of malignant neoplasia months
- Advanced chronic kidney disease (defined as 11.000/uL)
- Gastrointestinal bleeding in the preceding 3 month
- Any ongoing known presence of malignant neoplasia at admission with survival rate < 6
- Advanced chronic kidney disease (defined as eGFR < 30 ml/min or on dialysis)
Where it is running
- ASST GOM Niguarda — Milan, Italia, Italy (enrolling)
Full record on ClinicalTrials.gov
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