A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Heart Failure

In brief

This was a multicenter, randomized, placebo- and active-controlled, parallel-group, 24-week trial to investigate the efficacy, safety, and tolerability of XXB750 in participants with HFrEF/HFmrEF.

Key facts

Study ID

NCT06142383

Run by

Novartis Pharmaceuticals

People needed

136

Starts

2023-12-12

Expected to finish

2024-11-01

Last updated by the study team

2026-01-27

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current symptom(s) of HF NYHA class II-III and LVEF < 50%
• Elevated NT-proBNP levels at screening.
• Receiving standard of care background HF therapy.

You may not qualify if…

• Current acute decompensated HF or hospitalization for HF within 3 months prior to screening.
• Current symptomatic hypotension (for example dizziness/presyncope).
• K+ > 5.4 mmol/L at screening
• eGFR < 30 mL/min/1.73m2 at screening

Where it is running

• Novartis Investigative Site — Roma, RM, Italy
• Novartis Investigative Site — Roma, RM, Italy
• Novartis Investigative Site — Trieste, TS, Italy
• Novartis Investigative Site — Maebashi, Gunma, Japan
• Novartis Investigative Site — Kawasaki, Kanagawa, Japan
• Novartis Investigative Site — Sagamihara, Kanagawa, Japan
• Novartis Investigative Site — Matsumoto, Nagano, Japan
• Novartis Investigative Site — Lisbon, Portugal
• Novartis Investigative Site — Vila Nova de Gaia, Portugal
• Novartis Investigative Site — Bardejov, Slovakia, Slovakia
• Novartis Investigative Site — Košice, Slovakia, Slovakia
• Novartis Investigative Site — Martin, Slovakia, Slovakia
• Novartis Investigative Site — Nitra, Slovakia, Slovakia
• Novartis Investigative Site — Prešov, Slovakia, Slovakia
• Novartis Investigative Site — Svidník, Slovakia, Slovakia
• Novartis Investigative Site — Santiago Compostela, A Coruna, Spain
• Novartis Investigative Site — Huelva, Andalusia, Spain
• Novartis Investigative Site — Majadahonda, Madrid, Spain
• Novartis Investigative Site — Las Palmas GC, Spain
• Novartis Investigative Site — Madrid, Spain
• Novartis Investigative Site — Málaga, Spain
• Novartis Investigative Site — Valencia, Spain
• Novartis Investigative Site — Valencia, Spain
• Novartis Investigative Site — Taichung, Taiwan
• Novartis Investigative Site — Pordenone, PN, Italy

Full record on ClinicalTrials.gov

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