Water-based Activity to Enhance Recovery in Long COVID-19

Recruiting now · Not applicable

Conditions studied: Long COVID

In brief

This two-year study will evaluate the feasibility and safety of an exercise + cognitive training program to improve neurological symptoms of long-COVID. This is a two-phased trial: 1) an exercise phase and 2) a cognitive training phase. The exercise phase will be an aquatic based exercise program. A combination exercise + memory training programs designed for persons with cognitive impairment have significantly improved memory more than other single intervention groups (exercise only, cognitive training only) and given the success of combination training programs with healthy adults, it is important to adapt these programs for persons with neurological symptoms of long-COVID.

Key facts

Study ID

NCT06142253

Run by

VA Office of Research and Development

People needed

50

Starts

2024-12-01

Expected to finish

2026-12-31

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans, age 18 to 89, of any racial or ethnic group
• Previous COVID-19 infection at least 6 months after diagnosis documented in clinical record
• Persistent neurological symptoms (e.g., "brain fog", cognitive impairment) occurring within 3 months of onset of COVID-19 infection and lasting at least 8 weeks in duration
• Visual and auditory acuity to allow neuropsychological testing
• Willingness to participate in clinical trial for 8 months
• Approval by Primary Care Provider to participate in water-based physical exercise

You may not qualify if…

• Psychiatric Exclusions
• Current, uncontrolled severe psychotic disorder determined by the Mini International Neuropsychiatric Interview (MINI) Medical Exclusions
• History of neurological (e.g., multiple sclerosis, seizure disorder, stroke,) neurodegenerative (e.g., Parkinson's disease, Alzheimer's disease) or system illness affecting CNS function (e.g., liver failure, kidney failure, congestive heart failure, systemic cancer) occurring before COVID-19 diagnosis
• Current severe cardiac disease (e.g., uncontrolled atrial fibrillation, defined as mean 24 hour heart rate >85 beats/min, or 24 hour maximal ventricular rate >150 beats/min; uncontrolled ventricular arrhythmias, defined as recurrent ventricular tachycardia >3 beats in succession, or 24 hour PVC count >20%; active pericarditis or myocarditis; Class III/IV heart failure and / or ejection fraction < 20%; thrombophlebitis; pulmonary disease with a drop in O2 Sat with exercise to 90% without oxygen; embolism within past 6 months)
• Inability to participate in an exercise stress test
• Inability to read, verbalize understanding and voluntarily sign the Informed Consent

Where it is running

• VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States (enrolling)

Full record on ClinicalTrials.gov

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