Optimal Stimulation Parameters to Disrupt Epileptiform Activity

Completed · Not applicable

Conditions studied: Refractory Epilepsy

In brief

Open-loop electrical stimulation has been found to reduce spike activity and seizures, but determining the optimal parameters to achieve these effects requires a brute force trial-and-error approach that relies on subjective physician discretion. We will compare the performance of stimulation parameters identified in rodent models to the recommended parameters for neuromodulation used in clinical practice.

Key facts

Study ID

NCT06141668

Run by

Massachusetts General Hospital

People needed

28

Starts

2023-06-13

Expected to finish

2025-06-30

Last updated by the study team

2026-04-30

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing intracranial EEG investigation at Massachusetts General Hospital during presurgical epilepsy evaluation

You may not qualify if…

• Baseline spike ripple rate < 0.5/min.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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