Postprandial Urolithin Patterns Following Pecan Consumption

Status unconfirmed · Not applicable

Conditions studied: Change in Plasma Urolithins and Vitamin E

In brief

Pecan-enriched diets have been linked to improved cardiovascular health, including postprandial blood lipids and microvascular reactivity in older adults. This has led to recommendations to increase regular pecan consumption, however there is no consistent plasma measure of pecan intake. Traditionally, plasma tocopherols have been used, although they reach peak concentrations in plasma around 6-8 hours post pecan consumption, leading to high variability at 24 hours. Therefore, a more reliable biomarker of pecan consumption needs to be defined. The purpose of this study is to analyze the postprandial response of urolithins in human plasma after a pecan enriched meal and compare their appearance pattern to tocopherols. This single blind, randomized crossover trial is designed to provide two acute meal challenges for each participant (anticipated n=30, BMI 18.5 - 24.9, age 18-30y) with a washout period of \~14 days between each challenge. The intervention meal contains 68g of pecans and the control shake contains whipped cream instead of pecans, and the order of each meal will be randomly assigned. Blood draws will be collected at fasting (0-h) and every 2 hours until 8 hours postprandial, then at 12-, 24-, and 48h after the meal. The levels of urolithins and tocopherols will be quantified through liquid chromatography tandem mass spectrometry. To our knowledge, this is the first time urolithins will be tracked in plasma up to 48h post meal. This study will be used to establish of a new and more consistent dietary biomarker for pecans.

Key facts

Study ID

NCT06140602

Run by

University of Georgia

People needed

30

Starts

2023-07-18

Expected to finish

2024-07-30

Last updated by the study team

2023-11-24

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy individuals with BMI between 18.5 - 29.9 kg/m2
• Does not make use of medication (Birth control, and antidepressants SSRIs accepted)
• Does not make use of any nicotine products
• Has not been diagnosed with any diseases that can impair swallowing, digestion or lipid metabolism

You may not qualify if…

• Individuals with BMI < 18.5 or BMI > 29.9 kg/m2
• Individuals with chronic diseases of the gastrointestinal system
• Individuals currently taking antibiotics or any other medications not included on the inclusion criteria
• Individuals that have a current fever, or have any infection
• Individuals can not be taking prebiotics/probiotics supplementation, as well as multivitamin.

Where it is running

• Human Nutrition Lab — Athens, Georgia, United States (enrolling)

Full record on ClinicalTrials.gov

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