Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients

Recruiting now · Not applicable

Conditions studied: Septic Shock

In brief

The objective of this trial is to assess the beneficial and harmful effects of a restrictive strategy for administration of non-resuscitation fluids in adult patients with septic shock.

Key facts

Study ID

NCT06140147

Run by

Region Skane

People needed

1850

Starts

2023-11-27

Expected to finish

2028-07-01

Last updated by the study team

2026-04-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (≥ 18 years of age)
• Septic shock according to the Sepsis 3 criteria at any time within 12 hours after ICU admission (suspected or confirmed infection, plasma lactate above 2 mmol/L, and infusion of vasopressor/inotrope to maintain mean arterial pressure of 65mmHg or above after receiving adequate fluid resuscitation [> 1L within 12 h of screening]) and need for vasopressors at the time of screening.

You may not qualify if…

• Confirmed or suspected pregnancy
• Previous inclusion in the trial
• Screened more than 12 hours after ICU admission

Where it is running

• Helsinki University Hospital — Helsinki, Finland (enrolling)
• Östersund Hospital — Östersund, Sweden (enrolling)
• Stockholm South General Hospital (SÖS) — Stockholm, Sweden (enrolling)
• University Hospital of Umeå — Umeå, Sweden (enrolling)
• Uppsala University Hospital — Uppsala, Sweden (enrolling)
• Varberg Hospital — Varberg, Sweden (enrolling)
• Danderyd Hospital — Danderyd, Sweden (enrolling)
• Malar Hospital — Eskilstuna, Sweden (enrolling)
• Falun Hospital — Falun, Sweden (enrolling)
• Sahlgrenska University Hospital — Gothenburg, Sweden (enrolling)
• Östra Hospital — Gothenburg, Sweden (enrolling)
• Halmstad Hospital — Halmstad, Sweden (enrolling)
• Helsingborg Hospital — Helsingborg, Sweden (enrolling)
• Skåne University Hospital, Lund — Lund, Sweden (enrolling)
• Skåne University Hospital, Malmö — Malmö, Sweden (enrolling)
• Norrtälje Hospital — Norrtälje, Sweden (enrolling)
• Örebro University Hospital — Örebro, Sweden (enrolling)
• Kuopio University Hospital — Kuopio, Finland
• Tampere University Hospital — Tampere, Finland
• Turku University Hospital — Turku, Finland
• Södertälje Hospital — Södertälje, Sweden
• University Hospital of Wales — Cardiff, United Kingdom

Full record on ClinicalTrials.gov

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