Pharmacoscopy-guided Clinical Standard-of-care in r/r AML
Recruiting now · Phase 2
Conditions studied: AML, Adult
In brief
With an overall survival of below 12 months, the outcome of relapsed/refractory AML (RR AML) is poor, making it a critical challenge to identify effective therapies at this stage. The RAPID-01 trial aims to show for the first time in a randomized and controlled clinical trial that Pharmacoscopy (PCY), a functional precision medicine platform, helps improve clinical standard-of-care treatment selection for patients suffering from relapsed/refractory AML.
Key facts
- Study ID
- NCT06138990
- Run by
- ETH Zurich
- People needed
- 88
- Starts
- 2024-09-02
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2025-05-16
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient with refractory or relapsed AML according to ELN2022 criteria.
- Age 18-70 years.
- Considered to be eligible for intensive chemotherapy.
- Written informed consent.
You may not qualify if…
- Acute promyelocytic leukemia (APL) with PML-RARA or one of the other pathognomonic variant fusion genes/chromosome translocations.
- Blast crisis after chronic myeloid leukemia (CML).
- Considered not eligible for intensive chemotherapy.
- Condition of the patient does not allow to wait for PCY results (patient requires immediate treatment).
- PCY not working / patient sample did not pass the QC steps of PCY.
- Any other serious underlying medical, psychiatric, psychological, familial or geographical condition, which in the judgment of the principal investigator may interfere with the project or affect patient compliance.
- Legal incompetence or Subjects lacking capacity to provide informed consent.
- Participation in a clinical trial with an investigational drug within the 30 days preceding and during the present investigation.
Where it is running
- Inselspital Bern — Bern, Canton of Bern, Switzerland (enrolling)
- University Hospital Zurich — Zurich, Canton of Zurich, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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