The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma
Recruiting now
Conditions studied: Brain Network Connectivity, Postoperative Delirium, Dexmedetomidine, Propofol
In brief
Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
Key facts
- Study ID
- NCT06138340
- Run by
- Beijing Tiantan Hospital
- People needed
- 120
- Starts
- 2023-08-31
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-02-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed as unilateral supratentorial glioma by MRI
- Selective operation
- Age over 18 years old
- ASA I-II
- Right handedness
You may not qualify if…
- History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs
- History of intracranial surgery
- Drug and/or alcohol abuse
- History of dementia or mental illness
- Pregnant or lactating women
- Contraindications for MRI
- Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block
- Severe hepatic or renal dysfunction
Where it is running
- Beijing Tian Tan Hospital, Capital Medical University — Beijing, Beijing Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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