A Study to Learn About the Study Medicine Called PF-07868489 in Healthy Adult People and in People With Pulmonary Arterial Hypertension
Running, not enrolling · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Pulmonary Arterial Hypertension
In brief
The purpose of the study is to learn how the study medicine called PF-07868489 is tolerated and acts in healthy adult people and people with pulmonary arterial hypertension (PAH). Part A: An investigator- and participant-blind, sponsor-open, placebo-controlled, single ascending dose study to assess the safety, tolerability, and pharmacokinetics (PK) of PF-07868489 in healthy adult participants. Part B: A 24-week, randomized, double blind, placebo-controlled study to assess the safety, tolerability, PK, and pharmacodynamics (PD) of PF-07868489 in adult participants with PAH.
Key facts
- Study ID
- NCT06137742
- Run by
- Pfizer
- People needed
- 97
- Starts
- 2023-11-17
- Expected to finish
- 2026-09-02
- Last updated by the study team
- 2026-05-19
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
Where it is running
- Wesley Research Institute — Auchenflower, Queensland, Australia
- Université Libre de Bruxelles - Hôpital Erasme — Brussels, Bruxelles-capitale, Région de, Belgium
- UZ Leuven — Leuven, Vlaams-brabant, Belgium
- University Of Alberta Hospital — Edmonton, Alberta, Canada
- London Health Sciences Centre - Verspeeten Family Cancer Centre — London, Ontario, Canada
- London Health Sciences Centre - University Hospital — London, Ontario, Canada
- Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China
- The Second Xiangya Hospital of Central South University — Changsha, Hunan, China
- Zhongda Hospital Southeast University — Nanjing, Jiangsu, China
- Shanghai Pulmonary Hospital — Shanghai, Shanghai Municipality, China
- Vseobecna fakultni nemocnice v Praze — Prague, Czechia
- Institut Klinicke a Experimentalni Mediciny — Prague, Czechia
- CHRU de Brest — Brest, Finistère, France
- CHRU de Brest — Brest, Finistère, France
- Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord — Saint Priest En Jarez, Pays de la Loire Region, France
- Chu Grenoble Alpes — La Tronche, France
- Thoraxklinik-Heidelberg gGmbH — Heidelberg, Baden-Wurttemberg, Germany
- Universitätsklinikum Regensburg — Regensburg, Bavaria, Germany
- UKGM Gießen/Marburg — Giessen, Hesse, Germany
- Universitätsmedizin Greifswald — Greifswald, Mecklenburg-Vorpommern, Germany
- Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden — Dresden, Saxony, Germany
- Onassis Hospital — Kallithea, Attica, Greece
- University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA" — Chaïdári, Attikí, Greece
- AHEPA University General Hospital of Thessaloniki — Thessaloniki, Central Macedonia, Greece
- Pulmonary Hypertension Research Queensland Pty Ltd — Auchenflower, Queensland, Australia
Full record on ClinicalTrials.gov
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