Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer?

Recruiting now · Not applicable

Conditions studied: Embryo Transfer, Fertilization in Vitro, Coitus

In brief

The goal of this clinical trial is to test whether sexual intercourse the night after embryo transfer affects thawed embryo implantation rates. Women undergoing one of their first four frozen embryo transfers with a good quality embryo will be randomly assigned to two groups. The study group is subjected to have intercourse without using a condom at the evening/night after the embryo transfer, while the control group will abstain from intercourse for the next 48 hours after the transfer. Researchers will compare the ongoing pregnancy rates between the intervention group and the control group.

Key facts

Study ID

NCT06134609

Run by

Sheba Medical Center

People needed

656

Starts

2023-11-13

Expected to finish

2026-11-01

Last updated by the study team

2023-11-18

Who can join

Age: 18 and older, up to 41. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women age 18-41yrs.
• BMI (body mass index) of 18-35 kg/m².
• Patients undergoing one of their first four frozen embryo transfers.
• Patients transferring a good quality embryo, either a cleavage stage embryo or a day 5 blastocyst.

You may not qualify if…

• Patients age above 42.
• Moderate or poor-quality embryos.
• Patients with hydrosalpinx or uterus malformations.
• Patients who are not able or are not interested in having vaginal intercourse (same sex couples for example).
• Couples undergoing preimplantation genetic diagnosis when natural cycle frozen embryo transfer is planned (as they are instructed to avoid intercourse).

Where it is running

• Sheba Medical Center — Ramat Gan, Israel (enrolling)

Full record on ClinicalTrials.gov

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