A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight
Completed · Phase 3
Conditions studied: Obesity
In brief
This study will look at how well CagriSema compared to Tirzepatide helps people lower their body weight. CagriSema is a new investigational medicine developed by Novo Nordisk that combines Cagrilintide and Semaglutide. CagriSema is not yet being prescribed by doctors. Participant will get injections once a week throughout the treatment period. Participant will inject the study medicine under the skin with a pen injector in the thigh, stomach, or upper arm. After a first low dose, the study medicine will be gradually increased until reaching the planned dose (2.4 mg CagriSema or 15 mg Tirzepatide). The study will last for about one and a half year for each participant.
Key facts
- Study ID
- NCT06131437
- Run by
- Novo Nordisk A/S
- People needed
- 809
- Starts
- 2023-11-27
- Expected to finish
- 2026-01-09
- Last updated by the study team
- 2026-02-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female
- Age 18 years or above at the time of signing the informed consent
- Body mass index (BMI) of ≥ 30.0 kilogram per square meter (kg/m\^2)
You may not qualify if…
- Glycated haemoglobin (HbA1c) ≥ 6.5 % (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening
- History of type 1 or type 2 diabetes mellitus
Where it is running
- Univ of Alabama Birmingham — Birmingham, Alabama, United States
- Chambliss Clinical Trials LLC — Montgomery, Alabama, United States
- FDRC — Costa Mesa, California, United States
- Diablo Clinical Research, Inc. — Walnut Creek, California, United States
- Univ of Colorado at Denver — Aurora, Colorado, United States
- Yale University School Of Medicine — New Haven, Connecticut, United States
- Northeast Research Institute — Fleming Island, Florida, United States
- Jacksonville Ctr For Clin Res — Jacksonville, Florida, United States
- South Broward Research LLC — Miramar, Florida, United States
- Hope Clin Res & Wellness — Conyers, Georgia, United States
- East West Med Res Inst — Honolulu, Hawaii, United States
- Great Lakes Clinical Trials — Chicago, Illinois, United States
- Endeavor Health — Skokie, Illinois, United States
- Evanston Premier Hlthcr Res — Skokie, Illinois, United States
- Midwest Inst For Clin Res — Indianapolis, Indiana, United States
- Northern Pines Hlth Ctr, PC — Buckley, Michigan, United States
- StudyMetrix Research LLC — City of Saint Peters, Missouri, United States
- Comprehensive Weight Ctrl Prog — New York, New York, United States
- University of North Carolina — Chapel Hill, North Carolina, United States
- Medication Mgmnt, LLC_Grnsboro — Greensboro, North Carolina, United States
- PharmQuest Life Sciences LLC — Greensboro, North Carolina, United States
- Accellacare_NC — Raleigh, North Carolina, United States
- Accellacare — Wilmington, North Carolina, United States
- New Venture Medical Research — Wadsworth, Ohio, United States
- Lynn Institute of Norman — Norman, Oklahoma, United States
Full record on ClinicalTrials.gov
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