A Study of AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors
Recruiting now · Phase 1/Phase 2
Conditions studied: Advanced Solid Tumors That Are MTAP Deficient
In brief
This is a first time in human (FTiH) Phase I/IIa, open-label, multi-centre study of AZD3470 in participants with advanced or metastatic solid tumors with MTAP deficiency. The study consists of several study modules, evaluating the safety, tolerability, pharmacokinetic (PK), pharmacodynamics, and preliminary efficacy of AZD3470 as monotherapy or in combination with other anti-cancer agents.
Key facts
- Study ID
- NCT06130553
- Run by
- AstraZeneca
- People needed
- 334
- Starts
- 2024-01-18
- Expected to finish
- 2028-12-04
- Last updated by the study team
- 2026-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Research Site — Madrid, Spain (enrolling)
- Research Site — Seoul, South Korea (enrolling)
- Research Site — Barcelona, Spain (enrolling)
- Research Site — San Francisco, California, United States (enrolling)
- Research Site — New Haven, Connecticut, United States (enrolling)
- Research Site — Baltimore, Maryland, United States (enrolling)
- Research Site — Portland, Oregon, United States (enrolling)
- Research Site — Pittsburgh, Pennsylvania, United States (enrolling)
- Research Site — Providence, Rhode Island, United States (enrolling)
- Research Site — Fairfax, Virginia, United States (enrolling)
- Research Site — Melbourne, Australia (enrolling)
- Research Site — Beijing, China (enrolling)
- Research Site — Chengdu, China (enrolling)
- Research Site — Shanghai, China (enrolling)
- Research Site — Chūōku, Japan (enrolling)
- Research Site — Kashiwa, Japan (enrolling)
- Research Site — Amsterdam, Netherlands (enrolling)
- Research Site — Seoul, South Korea (enrolling)
- Research Site — West Hollywood, California, United States
- Research Site — Wuhan, China
- Research Site — Villejuif, France
Full record on ClinicalTrials.gov
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