Diagnosis and Comprehensive Treatment of Mediastinal Interventional Technique

Recruiting now

Conditions studied: Mediastinal Diseases

In brief

The goal of this observational study is to learn whether patients undergoing mediastinal disease diagnosis and combined treatment with intrapacial ultrasound-guided mediastinal opening techniques have greater clinical benefit. The main questions it aims to answer are: * Whether the mediastinal ultrasound-guided mediastinal opening technique is more beneficial for the diagnosis of benign or malignant mediastinal diseases. * Does the mediastinal ultrasound-guided mediastinal opening technique benefit the patient by ablating mediastinal masses using freezing, laser, or other means. Mediastinal diseases were diagnosed by lymph node biopsy combined with NGS, ROSE and other techniques using transairway ultrasound-guided mediastinal opening technique. Ablation of mediastinal malignancies is performed using techniques such as freezing or laser. Transbronchial lung biopsy(TBLB) may also be performed when necessary. Researchers will compare the experimental group with mediastinal opening and the control group without mediastinal opening to see if Mediastinal open technique benefits patients.

Key facts

Study ID

NCT06128681

Run by

Dan Liu

People needed

30

Starts

2021-12-01

Expected to finish

2026-12-31

Last updated by the study team

2026-02-10

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Radiographic abnormalities of mediastinum
• Can tolerate general anesthesia
• Can tolerate bronchoscopy and has the condition to have mediastinal biopsy and treatment

You may not qualify if…

• Imaging or other tests can make a definitive diagnosis
• Cannot tolerate general anesthesia or tracheoscopic surgery
• Patients cannot sign informed consent forms

Where it is running

• Tianjin Medical University General Hospital — Tianjin, China (enrolling)

Full record on ClinicalTrials.gov

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