High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease

Completed · Not applicable · Has a placebo group

Conditions studied: Coronary Artery Bypass Graft, CABG

In brief

Background/aim: Endothelial function is closely associated with coronary artery health among individuals being treated for heart disease. An impairment in endothelial function promotes arterial stiffening that directly contributes to elevated systolic blood pressure as a result of increased vascular resistance. Inspiratory muscle training is simply a form of training consisting of repeated inspirations against resistance. Inspiratory muscle training has also been applied to patients with chronic disease or as an additional therapy for cardiac rehabilitation and it has proven to be safe in these groups. Few studies in the literature examined the effects of high-intensity inspiratory muscle training in this population, however, these studies did not examine the direct effects of inspiratory muscle training on vascular function. To the best of our knowledge, the effects of inspiratory muscle training in patients with heart disease on endothelial function and arterial stiffness prior to starting cardiac rehabilitation have not been investigated. This study aims to investigate and interpret whether high-intensity inspiratory muscle training, beyond the usual care of heart disease, improves endothelial function and arterial stiffness. Methods: The study was designed as a randomized controlled trial. Patients will be allocated for inspiratory muscle training (IMT) with 60% of maximum inspiratory pressure (MIP) or sham inspiratory muscle training (Sham-control), for 4 weeks. In both groups, before and after 4-week training, cardiovascular functions will be measured and compared.

Key facts

Study ID

NCT06127147

Run by

University of Illinois at Chicago

People needed

11

Starts

2023-12-20

Expected to finish

2024-06-15

Last updated by the study team

2026-01-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged >18 years old
• Be able to walk independently.
• Had coronary artery bypass graft (CABG) surgery, history of percutaneous coronary interventions, heart failure, and/or myocardial infarction.
• Sufficient English language comprehension and cognitive ability to understand the study protocol, give informed consent and follow instructions.

You may not qualify if…

• Being a current smoker (or tobacco).
• Having a diagnosed chronic disease such as inflammatory bowel disease/irritable bowel syndrome, cerebrovascular diseases, COPD, chronic kidney disease requiring dialysis, neurological disorders, or diseases that may affect motor/cognitive function [multiple sclerosis, Parkinson's disease, polio, Alzheimer's disease, dementia, or other brain diseases of ageing])
• Getting a score below 24 on the Standardized Mini Mental Test
• Using antipsychotic medications commonly used to treat schizophrenia or schizoaffective disorders (i.e., haloperidol)
• Having had any other previous cardiothoracic operation except CABG (e.g. Pneumonectomy, lobectomy, etc.)
• Having a history of unstable-angina
• Having had pneumonia in the last 3 months

Where it is running

• University of Illinois at Chicago — Chicago, Illinois, United States
• University of Illinois Chicago — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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