Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
Recruiting now · Not applicable
Conditions studied: Liver Dysfunction, Liver Metastasis Colon Cancer, Liver Regeneration
In brief
The primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy. The main questions it aims to answer are: 1. Does high-dose insulin therapy improve liver function in the pre-operative setting? 2. What is the effect of high-dose insulin therapy on liver function and liver regeneration after a liver venous deprivation (LVD) procedure? 3. What is the relationship between volume hypertrophy and function in the regenerating liver? Participants will receive a 6-hour infusion of insulin and dextrose to maintain a hyperinsulinemic-normoglycemic state in the weeks prior to planned liver surgery to assess its effect on liver function measured by 99m-Tc-Mebrofenin hepatobiliary scintigraphy.
Key facts
- Study ID
- NCT06126419
- Run by
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- People needed
- 70
- Starts
- 2023-11-08
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2024-11-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 18 years old
- Candidate for major liver resection
- Resectable colorectal liver metastasis
You may not qualify if…
- Inability to give consent
- Type 1 diabetes mellitus
- Uncontrolled blood glucose levels (fasting level > 10 mmol/L)
- Unresectable colorectal liver metastasis
- Extrahepatic metastatic disease that is unresectable
Where it is running
- McGill Univeristy Health Centre — Montreal, Quebec, Canada (enrolling)
Full record on ClinicalTrials.gov
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