Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

Running, not enrolling · Phase 2 · Has a placebo group

Conditions studied: Heart Failure

In brief

The purpose of this study is to evaluate the safety, tolerability, and exposure-response (E-R) of BMS-986435/MYK-224 in participants with symptomatic Heart Failure with Preserved Ejection Fraction (HFpEF).

Key facts

Study ID

NCT06122779

Run by

Bristol-Myers Squibb

People needed

227

Starts

2023-11-07

Expected to finish

2026-12-14

Last updated by the study team

2026-07-30

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult participants with stable, symptomatic HFpEF with a normal heart pumping ability.

You may not qualify if…

• Participants must not have a known diagnosis of obstructive or genetic hypertrophic cardiomyopathy or infiltrative/storage disorder such as cardiac amyloidosis, or any other acute or serious condition that could interfere with assessments during the study or may pose a risk to the participant.
• Other protocol-defined Inclusion/Exclusion criteria apply.

Where it is running

• Local Institution - 0010 — Valencia, Spain
• Local Institution - 0002 — Birmingham, Alabama, United States
• Local Institution - 0096 — Lakewood, Colorado, United States
• Local Institution - 0077 — Jacksonville, Florida, United States
• Local Institution - 0003 — Miami, Florida, United States
• Local Institution - 0099 — Miami, Florida, United States
• Local Institution - 0004 — Chicago, Illinois, United States
• Local Institution - 0005 — Hazel Crest, Illinois, United States
• Local Institution - 0029 — Indianapolis, Indiana, United States
• Local Institution - 0028 — St Louis, Missouri, United States
• Local Institution - 0117 — Hackensack, New Jersey, United States
• Local Institution - 0070 — Albany, New York, United States
• Local Institution - 0105 — Brooklyn, New York, United States
• Local Institution - 0008 — New York, New York, United States
• Local Institution - 0059 — Rochester, New York, United States
• Local Institution - 0076 — Rochester, New York, United States
• Local Institution - 0094 — Rosedale, New York, United States
• Local Institution - 0095 — Durham, North Carolina, United States
• Local Institution - 0016 — Oklahoma City, Oklahoma, United States
• Local Institution - 0078 — Abington, Pennsylvania, United States
• Local Institution - 0001 — Tullahoma, Tennessee, United States
• Local Institution - 0104 — Austin, Texas, United States
• Local Institution - 0036 — Dallas, Texas, United States
• Local Institution - 0015 — Houston, Texas, United States
• Local Institution - 0018 — Seville, Spain

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.