WOE of Anti-CD20 Therapies
Completed
Conditions studied: Multiple Sclerosis
In brief
The nature, intensity, and prevalence of this wearing-off effect remain poorly understood. To our knowledge, there is no consensus in the literature on what symptoms constitute a wearing-off effect, nor is there a single validated scale that measures wearing-off effect. The current study will explore the wearing-off effect associated with OCR and OMB, using a variety of validated scales assessing MS symptoms (i.e., fatigue, mobility, pain, depression, cognition), as well as some global questions on wearing-off. In addition, impact of worsening of MS symptoms on patients' health-related quality of life (HRQoL) and their work productivity will be assessed using relevant MS-specific validated scales
Key facts
- Study ID
- NCT06121349
- Run by
- Novartis Pharmaceuticals
- People needed
- 157
- Starts
- 2023-12-04
- Expected to finish
- 2025-06-13
- Last updated by the study team
- 2025-07-11
Who can join
Age: 21 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- OCR sample:
- Self-reported diagnosis of RMS, SPMS or CIS
- ≥21 years old at the time of initial contact
- Under treatment with OCR at the time of initial contact
- Have been on OCR for ≥ 1 year at the time of initial contact (i.e., prevalent users)
- Able to answer the questionnaires in English
- OMB sample
- Self-reported diagnosis of RMS, SPMS or CIS
- ≥21 years old at the time of initial contact
- Under treatment with OMB at the time of initial contact
- Have been on OMB for ≥6 months at the time of initial contact (i.e., prevalent users)
- Able to answer the questionnaires in English
You may not qualify if…
- OCR sample:
- Currently participating in a clinical trial involving MS drugs
- Last Ocrevus infusion was less than 3 months back
- OMB sample:
- Currently participating in a clinical trial involving MS drugs
Where it is running
- Novartis Investigative Site — East Hanover, New Jersey, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.