Precision Dosing of Metformin in Youth With T2D
Recruiting now · Early Phase 1
Conditions studied: Type 2 Diabetes
In brief
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
Key facts
- Study ID
- NCT06120881
- Run by
- University of California, San Francisco
- People needed
- 20
- Starts
- 2024-04-25
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2025-12-23
Who can join
Age: 10 and older, up to 21. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 10-21 years
- Provider diagnosis of T2D
- Stable medication regimen for 2 weeks before screening visit (No addition or removal of medications and no more than 20% change in insulin dose)
- ≥ 1 month from T2D diagnosis
- Taking regular metformin (not extended-release formula)
- Ability to wear CGM for a total of 6 weeks while in the study.
- English or Spanish speakers.
- Willing to abide by recommendations and study procedures.
- Willing and able to sign the Informed Consent Form (ICF) and/or has a parent or guardian willing and able to sign the ICF.
- Participant and parent(s)/guardian(s) willingness to participate in all training sessions as directed by study staff. Written informed consent (and assent when applicable) obtained from subject or subject's legal representative and ability for subject to comply with the requirements of the study.
You may not qualify if…
- Pancreatic autoantibody positivity (GAD-65, insulin, IA-2, ICA 512, Zn-T8).
- Known history of ongoing renal or hepatic disease.
- Known history of significant mental illness or developmental delay impacting the ability to complete study activities independently.
Where it is running
- UCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic — Oakland, California, United States (enrolling)
- UCSF Benioff Children's Hospital San Francisco, Madison Clinic for Pediatric Diabetes — San Francisco, California, United States (enrolling)
Full record on ClinicalTrials.gov
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