A Study of LY3872386 in Healthy Participants and Participants With Atopic Dermatitis
Stopped early · Phase 1 · Has a placebo group
Conditions studied: Healthy, Atopic Dermatitis
In brief
The main purpose of this study is to evaluate the safety and tolerability of LY3872386 in healthy participants and participants with atopic dermatitis. The safety of prednisone is also evaluated in healthy participants. Blood tests will be performed to investigate how the body processes the LY3872386 following single and multiple dosing in healthy participants and participants with atopic dermatitis. Blood tests will also be performed to investigate how the body processes the prednisone in healthy participants. The study is conducted in three parts (part A, B and C). The study will last up to approximately 85, 183 and 44 days for parts A, B, and C, respectively.
Key facts
- Study ID
- NCT06119529
- Run by
- Eli Lilly and Company
- People needed
- 18
- Starts
- 2023-11-01
- Expected to finish
- 2024-04-08
- Last updated by the study team
- 2025-10-03
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Part A and C:
- Overtly healthy as determined by medical evaluation
- To qualify as Japanese for the purpose of this study, the participant must be first generation Japanese, defined as the participant's biological parents and all of the participant's biological grandparents must be of exclusive Japanese descent, and must have been born in Japan
- To qualify as Chinese for the purpose of this study, the participant must be, at a minimum, third-generation Chinese, defined as all 4 of the participant's biological grandparents must be of exclusive Chinese descent and born in China
- Have a body mass index of 18.0 to 32.0 kilograms per square meter (kg/m²), inclusive
- Male participants who agree to use highly effective or effective methods of contraception and women not of childbearing potential may participate in part A and C
- Part B:
- Participants who have a diagnosis of atopic dermatitis at least 12 months prior to screening as defined by the American Academy of Dermatology
- Have a history, documented by a physician and/or investigator, of inadequate response to existing topical medications within 6 months preceding screening, or participants who failed systemic therapies intended to treat atopic dermatitis or a history of intolerance to topical therapy
- Have a body mass index of 18.0 to 38.0 kilograms per square meter (kg/m²), inclusive
- Male participants who agree to use highly effective or effective methods of contraception, women not of childbearing potential and women of childbearing potential may participate in part B
You may not qualify if…
- Women who are pregnant and/or lactating
- Participants who have received live vaccine(s) (including attenuated live vaccines) or Bacillus Calmette- Guérin within 35 days of screening
- Have a history or presence of multiple or severe allergies or an anaphylactic reaction to prescription or nonprescription drugs
- Have a known history of diabetes
- Have fasting glucose level of ≥126 milligrams per deciliter (mg/dL) and glycated hemoglobin ≥6.5 percent (%) and/or taking anti-diabetes medications at screening
- Have known history of osteoporosis
Where it is running
- CenExel ACT — Anaheim, California, United States
- Fortrea Clinical Research Unit — Daytona Beach, Florida, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.