Microbiome and Host Susceptibility in Severe Pneumonia, a Prospective, Multicenter, Cohort Study

Recruiting now

Conditions studied: Severe Pneumonia

In brief

This study was a prospective multicenter cohort of severe pneumonia. And by collecting clinical samples to clarify the correlation between lung microbiome, intestinal microbiome, host susceptibility, and prognosis of severe pneumonia patients.

Key facts

Study ID

NCT06114784

Run by

First Affiliated Hospital of Zhejiang University

People needed

2000

Starts

2023-09-25

Expected to finish

2026-12-31

Last updated by the study team

2025-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• New lung infection that meets one of the following definitions: the patient receives mechanical ventilation (invasive or non-invasive) due to acute respiratory failure, with a PEEP level of 5cm or above; Patients receiving high flow oxygen therapy with a FiO2 of 50% or more and a PaO2: FiO2 ratio below 300

You may not qualify if…

• Expected length of stay in ICU is less than 1 day
• Pregnant

Where it is running

• The Second Affiliated Hospital of Zhengzhou University — Zhengzhou, China (enrolling)
• First Affiliated Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (enrolling)
• Shulan (Hangzhou) hospital — Hangzhou, China (enrolling)
• Tongde Hospital of Zhejiang Province — Hangzhou, China (enrolling)
• the First People's Hospital of Huzhou — Huzhou, China (enrolling)
• The First Hospital of Jiaxing — Jiaxing, China (enrolling)
• Lanxi Hospital of Traditional Chinese Medicine — Lanxi, China (enrolling)
• Lishui People's Hospital — Lishui, China (enrolling)
• The First People's Hospital of Pinghu — Pinghu, China (enrolling)
• Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University — Taizhou, China (enrolling)
• Wenzhou Central Hospital — Wenzhou, China (enrolling)
• Xi'an People's Hospital (Xi'an No.4 Hospital) — Xi'an, China (enrolling)
• Henan Provincial People's Hospital — Zhengzhou, China (enrolling)
• The Fifth Clinical Medical College of Henan University of Chinese Medicine — Zhengzhou, China (enrolling)
• The Second Affiliated Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, China

Full record on ClinicalTrials.gov

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