Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches

Recruiting now · Phase 1 · Has a placebo group

Conditions studied: Brain Concussion, Mild Traumatic Brain Injury, Headache, Post-Concussion Symptoms

In brief

This study aims to examine the long-term effect of repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, on chronic headaches following mild traumatic brain injury (mTBI). rTMS has been shown to be effective in reducing chronic headaches without side effects commonly seen in medications, such as sleepiness and addiction. This study uses rTMS to manage chronic headaches to improve post-concussion symptoms and reduce the economic burden due to delayed recovery. This project aims to better identify biomarkers for diagnosis and prognosis and maximize recovery from mTBI.

Key facts

Study ID

NCT06112093

Run by

State University of New York - Upstate Medical University

People needed

60

Starts

2023-10-23

Expected to finish

2027-10-23

Last updated by the study team

2025-10-10

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18 - 55 years old
• mTBI with loss of consciousness for less than 30 min, initial Glasgow Coma Scale between 13 and 15, or post-traumatic amnesia for ≤ 24 hours
• diagnosis of persistent post-traumatic headache according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) criteria
• headache develops within 7 days after head trauma
• headache persists for >=3 months after head trauma despite receiving standard care
• average persistent headache intensity is >= 3/10 of the numerical rating scale (NRS) on >=3days/week
• no evidence of radiculopathy or peripheral neuropathy on electromyography or clinical evaluation
• no evidence of other possible causes of headaches

You may not qualify if…

• history of chronic headache diagnoses such as migraine, tension, or cluster headaches prior to the incidence of mTBI
• history of other neurologic conditions with medications affecting the central nervous system
• contraindications of receiving TMS (e.g., a history of epileptic seizure and having implants like a cardiac pacemaker or intracerebral vascular clip

Where it is running

• SUNY Upstate Medical University — Syracuse, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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