Population Health Approach to Optimizing Medications in Older Adults
Running, not enrolling · Not applicable
Conditions studied: Medication Adverse Effects, Older Adults (65 Years and Older), Polypharmacy, Polypharmacy Patients, Deprescribing
In brief
This randomized controlled pragmatic pilot study examines the feasibility and acceptability of a population health-based deprescribing intervention that leverages a polypharmacy risk prediction model. It includes four arms (2 intervention and 2 control arms) and uses a parallel arm study design.
Key facts
- Study ID
- NCT06110156
- Run by
- Cedars-Sinai Medical Center
- People needed
- 100
- Starts
- 2025-05-19
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-03-27
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients will be invited to enroll in the study if they are in the top decile of risk selected by a risk prediction model of polypharmacy-related adverse events. The risk prediction model includes variables such as: age, sex, recent healthcare encounters, current and past medications, current and past lab tests, current and past diagnoses.
- 65 years of age or older
- Have a primary care clinician within the Cedars-Sinai Health System who uses MyCSLink (electronic health record used by Cedars-Sinai).
- Part of a Cedars-Sinai Health System population health registry (e.g., enrolled in an Accountable Care Organization, Medicare Advantage plan, or Primary Care First program)
- Diagnosis of Mild Cognitive Impairment or Dementia at baseline (for one intervention group) on the problem list
- Exclusion criteria include:
- Patients for whom there is an active substance use disorder (defined by a physician) and thus for whom the intervention may not be appropriate
- Patients with an organ transplant
- Visits with a Cedars-Sinai Medical Center pharmacist for a polypharmacy consult within the last 6 months
- Patients who previously indicated in the EHR that they wish to opt out of participating in research studies.
- Patients enrolled in CS360, a program for highly complex medical patients, who already receive polypharmacy services.
Where it is running
- Cedars-Sinai Medical Center — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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