A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment Period

Completed · Phase 3 · Has a placebo group

Conditions studied: Plaque Psoriasis

In brief

The main aim of this study is to show how well TAK-279 reduces the skin plaques compared to placebo, in participants with moderate-to-severe plaque psoriasis. Participants will be assigned to one of the 3 study treatments (TAK-279, apremilast (an approved treatment), or a placebo). Participants will be in the study for up to 69 weeks.

Key facts

Study ID

NCT06108544

Run by

Takeda

People needed

1108

Starts

2023-11-06

Expected to finish

2025-11-07

Last updated by the study team

2025-11-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Plaque psoriasis for at least 6 months.
• Moderate to severe disease.
• Candidate for phototherapy or systemic therapy.

You may not qualify if…

• Other forms of psoriasis.
• History of recent infection.
• Prior exposure to TAK-279 or active comparator.
• Other protocol defined inclusion/exclusion criteria apply.

Where it is running

• Cahaba Dermatology Skin Health Center — Hoover, Alabama, United States
• Medical Dermatology Specialists — Phoenix, Arizona, United States
• Noble Clinical Research — Tucson, Arizona, United States
• Johnson Dermatology Clinic — Fort Smith, Arkansas, United States
• Burke Pharmaceutical Research — Hot Springs, Arkansas, United States
• Zenith Research, Inc. — Beverly Hills, California, United States
• UNISON Clinical Trials (Shahram Jacobs md inc.) — Encino, California, United States
• First OC Dermatology Research Inc. — Fountain Valley, California, United States
• Long Beach Research Institute, LLC — Long Beach, California, United States
• Metropolis Dermatology Downtown LA - Probity - PPDS — Los Angeles, California, United States
• Northridge Clinical Trials — Northridge, California, United States
• TCR Medical Corporation — San Diego, California, United States
• University Clinical Trials — San Diego, California, United States
• Dermatology Institute and Skin Care Center — Santa Monica, California, United States
• Revival Research Corporation - Florida - ClinEdge - PPDS — Doral, Florida, United States
• Florida Academic Centers Research — Miami, Florida, United States
• San Marcus Research Clinic Inc — Miami Lakes, Florida, United States
• FXM Research Miramar — Miramar, Florida, United States
• Lenus Research & Medical Group — Sweetwater, Florida, United States
• Advanced Clinical Research Institute (ACRI) - Florida — Tampa, Florida, United States
• Olympian Clinical Research - 6331 Memorial Hwy — Tampa, Florida, United States
• Divine Dermatology and Aesthetics, LLC — Atlanta, Georgia, United States
• Advanced Medical Research, PC — Atlanta, Georgia, United States
• Skin Care Physicians of Georgia — Macon, Georgia, United States
• Total Dermatology — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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