Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure

Stopped early · Not applicable

Conditions studied: Acute Hypercapnic Respiratory Failure

In brief

The study aims to find if using a Biphasic Cuirass Ventilation is as effective as using a Non invasive Positive Pressure Ventilation in patients admitted with acute hypercapnic respiratory failure.

Key facts

Study ID

NCT06108284

Run by

University of Missouri-Columbia

People needed

50

Starts

2024-04-03

Expected to finish

2025-06-21

Last updated by the study team

2026-02-13

Who can join

Age: 21 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• admission diagnosis of hypercapnic respiratory failure
• pH between 7.20-7.35 in an ABG sample or pH between 7.16-.31 in a venous sample.

You may not qualify if…

• age <21
• Pregnant
• Inmate/Prisoner
• Contraindication for cuirass ventilator (open chest wound, flail chest, prior thoracic surgery)
• Chest wall defect, neuromuscular disease or diaphragmatic paralysis.
• BMI >50

Where it is running

• University of Missouri Hospitals — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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