Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up

Recruiting now · Has a placebo group

Conditions studied: Asthma, Pulmonary Function, Wheezing, In Utero Nicotine

In brief

The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring. This is an additional continuation of the Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) trial, to follow the offspring through 10 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's airway function tests. The investigators aim to demonstrate sustained improvement in airway/pulmonary function and trajectory through 10 years of age.

Key facts

Study ID

NCT06106646

Run by

Oregon Health and Science University

People needed

225

Starts

2023-10-11

Expected to finish

2028-08-01

Last updated by the study team

2025-03-18

Who can join

Age: 6 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Women and their offspring randomized to vitamin C versus placebo during pregnancy as well as pregnant nonsmokers and their offspring enrolled as the reference group in the original VCSIP study

You may not qualify if…

• participants who specifically withdraw consent

Where it is running

• Indiana University — Indianapolis, Indiana, United States (enrolling)
• Oregon Health and Science University (OHSU) — Portland, Oregon, United States (enrolling)

Full record on ClinicalTrials.gov

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