Neurobehavioral Profiles of Adaptive Stress Responses in Individuals With Alcohol Use Disorder

Recruiting now · Not applicable

Conditions studied: Alcohol Use Disorder, Stress Reaction, Social Stress, Craving, Relapse, Addiction, Alcohol, Risk Behavior

In brief

The goal of this observational study is to investigate longitudinal stress response profiles and adaptive versus non-adaptive stress responses in alcohol use disorder. The main questions the projects aims to answer are: What are the neurobehavioral underpinnings of adaptive stress responses and resilience to repeated stress exposure with regards to: * alcohol craving? * alcohol use? * their modulation by prior stress exposure, social interactions, coping strategies and individual health behavior? Participants will: * be exposed to an established experimental stress-induction protocol, the Trier Social Stress Test * be exposed to their favorite drink in a bar lab environment * be assessed using fMRI to determine their neural alcohol cue reactivity, response inhibition, and emotion processing * conduct an ambulatory phase to assess stressors, alcohol craving, substance use and details on social interactions, health behavior and coping strategies using ecological momentary assessment tools.

Key facts

Study ID
NCT06105853
Run by
Central Institute of Mental Health, Mannheim
People needed
100
Starts
2023-12-01
Expected to finish
2027-06-30
Last updated by the study team
2025-04-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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