Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)

Recruiting now

Conditions studied: CTEPH

In brief

1. To identify biological sex differences in baseline RV function in CTEPH 2. To identify biological sex differences in recovery of RV function after PTE surgery in CTEPH 3. To determine if sex hormone levels relate to RV function at CTEPH diagnosis and during recovery after PTE.

Key facts

Study ID

NCT06105242

Run by

Intermountain Health Care, Inc.

People needed

10

Starts

2022-05-30

Expected to finish

2026-12-31

Last updated by the study team

2023-10-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (≥18 years old) patients diagnosed with CTEPH per current guideline standard42
• Subject must have a baseline TTE (within 3 months of diagnosis) with adequate images for RVGLS analysis
• Subject must have a right heart catheterization (RHC) at the time of diagnosis
• To be included in the Aim 2 analysis, patients must undergo PTE surgery and have a TTE performed 3-9 months after surgery with adequate images for RVGLS strain analysis

You may not qualify if…

• Unclear or mixed PH diagnosis as designated by an expert clinician at Intermountain PH center
• Any subjects <18 years of age
• Patients diagnosed during pregnancy
• Patients without a TTE and RHC at time of diagnosis

Where it is running

• Intermountain Medical Center — Murray, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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