Validation of a Novel Cerebellar-striatal Satiety Circuit in Humans

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Appetitive Behavior, Obesity

In brief

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study satiety in healthy individuals. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about the role of the cerebellum in satiety.

Key facts

Study ID

NCT06105164

Run by

Brigham and Women's Hospital

People needed

150

Starts

2024-12-05

Expected to finish

2029-08-01

Last updated by the study team

2025-12-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy individuals aged 18 to 65
• BMI of 20-35.0 kg/m2
• Normal or corrected-to-normal vision
• Good general health
• Ability to understand and willingness to sign written informed consent document

You may not qualify if…

• Current and/or past medical conditions
• Current and/or past eating disorder
• On a restricted diet and/or taking weight loss medication(s)
• History of bariatric surgery
• Weight fluctuation >3% in past 3 months
• Recent history of illicit recreational drug abuse
• Current nicotine use
• Intellectual disability
• Conditions that might result in increased risks of side effects or complications from TMS or MRI

Where it is running

• McLean Hospital — Belmont, Massachusetts, United States (enrolling)
• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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