Study of B/F/TAF in Participants Switching From CAB + RPV to B/F/TAF for HIV-1 Infection (EMPOWER)
Completed · Phase 4
Conditions studied: HIV-1-infection
In brief
The goal of this clinical study is to learn how safe it is to switch to an oral therapy of Bictegravir/Emtricitabine/Tenofovir (B/F/TAF) from Cabotegravir + Rilpivirine (CAB+RPV) in participants living with virologically suppressed human immunodeficiency virus type 1 (HIV-1), meaning participants with HIV RNA levels below detectable levels. The primary objective of this study is to assess the safety of switching to B/F/TAF in virologically suppressed participants unable/unwilling to continue on CAB+RPV intramuscular (IM) injections or wishing to switch to oral therapy through Week 12.
Key facts
- Study ID
- NCT06104306
- Run by
- Gilead Sciences
- People needed
- 33
- Starts
- 2023-12-13
- Expected to finish
- 2025-04-23
- Last updated by the study team
- 2026-02-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Franco Felizarta, MD — Bakersfield, California, United States
- BIOS Clinical Research — Palm Springs, California, United States
- UC San Diego AntiViral Research Center (AVRC) — San Diego, California, United States
- Midway Immunology and Research Center — Ft. Pierce, Florida, United States
- Bliss Health — Orlando, Florida, United States
- Indiana University Infectious Diseases Research — Indianapolis, Indiana, United States
- Boston Medical Center — Boston, Massachusetts, United States
- Las Vegas Research Center — Las Vegas, Nevada, United States
- Saint Michael's Medical Center — Newark, New Jersey, United States
- MultiCare Rockwood Main Clinic — Spokane, Washington, United States
- Hamilton Health Sciences-SIS Clinic — Hamilton, Canada
- St. Michael's Hospital — Toronto, Canada
- University Health Network - Toronto General Hospital — Toronto, Canada
- CHU Bordeaux - Hopital Saint-Andre — Bordeaux, France
- APHM - Hospital Sainte Marguerite — Marseille, France
- CHR Orleans — Orléans, France
- Centre Hospitalier Annecy Genevois — Pringy, France
- HU de Strasbourg - Nouvel Hopital Civil — Strasbourg, France
Full record on ClinicalTrials.gov
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