Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome
Recruiting now · Not applicable
Conditions studied: Ischemic Heart Disease, Non STEMI, Angina Pectoris, Unstable, Coronary Disease, Heart Attack, Acute Myocardial Infarction (AMI), Randomized Controlled Trial, Diagnostic Imaging, Coronary Stenoses, Coronary Artery Disease, Multidetector Computed Tomography, Percutaneous Coronary Intervention
In brief
Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS). If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.
Key facts
- Study ID
- NCT06101862
- Run by
- Rigshospitalet, Denmark
- People needed
- 2300
- Starts
- 2023-10-01
- Expected to finish
- 2036-10-01
- Last updated by the study team
- 2025-02-19
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Admitted with non-ST-segment elevation myocardial infarction or unstable angina pectoris and an indication for subacute ICA
- Elevated troponin or ischemic electrocardiographic changes
- Written informed consent
You may not qualify if…
- Instability requiring acute or emergent ICA
- History of percutaneous coronary intervention or coronary artery bypass grafting
- Estimated glomerular filtration rate \< 30 mL/min/1.73m2
- Probable type 2 acute myocardial infarction
- Severe valvular heart disease as primary diagnosis or potential need for valve intervention
- History of spontaneous coronary artery dissection
- Expected poor quality of the CCTA
- Prior CCTA or ICA during index admission or within 1 week
- Known allergy to beta-blockers or contrast agent
- Pregnant or nursing
- Previously randomized in this trial
Where it is running
- Herlev and Gentofte Hospital — Copenhagen, Hellerup, Denmark (enrolling)
- Bispebjerg Hospital — Bispebjerg, Denmark (enrolling)
- Rigshospitalet — Copenhagen, Denmark (enrolling)
- Zealand University Hospital — Copenhagen, Denmark (enrolling)
- North Zealand Hospital — Hillerød, Denmark (enrolling)
- Hvidovre Hospital — Hvidovre, Denmark (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.