Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus

Completed · Phase 3 · Has a placebo group

Conditions studied: Keratoconus

In brief

A Multicenter, Randomized, Double-Masked, Sham-Controlled, Parallel-Group Phase 3 Study to Evaluate the Efficacy and Safety of Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus

Key facts

Study ID

NCT06100952

Run by

Epion Therapeutics

People needed

398

Starts

2023-11-01

Expected to finish

2026-03-17

Last updated by the study team

2026-06-25

Who can join

Age: 8 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of keratoconus

You may not qualify if…

• Minimal corneal thickness < 350 microns
• Non-keratoconic ectatic disease
• Contraindications or hypersensitivities to any required study medications
• Pregnancy or breastfeeding
• Certain concomitant ocular conditions

Where it is running

• Schwartz Laser Eye Center — Scottsdale, Arizona, United States
• Catalina Eye Center — Tucson, Arizona, United States
• Inland Eye Specialists — Murrieta, California, United States
• University of Colorado — Aurora, Colorado, United States
• Chicago Cornea Consultants — Highland Park, Illinois, United States
• Claris Vision LLC Eye Health Vision Centers - Dartmouth — North Dartmouth, Massachusetts, United States
• Truhlsen Eye Institute — Omaha, Nebraska, United States
• Providence Eye and Laser Specialists — Charlotte, North Carolina, United States
• VRF Eye Specialty Group — Memphis, Tennessee, United States
• Dell Laser Consultants — Austin, Texas, United States
• Hoopes Vision — Draper, Utah, United States
• Virginia Eye Consultants — Norfolk, Virginia, United States

Full record on ClinicalTrials.gov

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