Biomarkers in the Diagnosis and Prognosis of NAFLD
Recruiting now
Conditions studied: NAFLD, Obesity, Liver Fibrosis, Diabetes Mellitus, Type 2
In brief
Fibrosis is considered the leading cause of liver diseases and related mortality. Specifically, hepatic fibrosis is regarded as the consequence of reparative mechanisms initiated by hepatocytes in response to chronic damage. In Western countries, the main known etiologies include hepatitis (B and C), alcoholism, and non-alcoholic steatohepatitis (NASH). In particular, obesity is a determining factor in the onset and development of NASH. Alarming statistical data indicate that over 30% of the world's population is obese, and this eating disorder is increasingly affecting young people. NASH is a chronic disease that can present different degrees of fibrosis and, as the final stage, lead to the development of liver cirrhosis. Currently, the only accurate diagnostic and assessment system for this condition is liver biopsy, as there are no accurate non-invasive clinical tests available. The aim of this project is to identify (in silico) potential biomarkers involved in the development and progression of hepatic fibrosis and validate their presence and quantity in serum or plasma samples from obese patients (at-risk population). This would avoid the need for a liver biopsy and allow "at-risk" patients to undergo a simple ambulatory blood draw. Additionally, performing elastometry of the liver would allow for comparison of radiological results with laboratory findings.
Key facts
- Study ID
- NCT06098417
- Run by
- University of Trieste
- People needed
- 500
- Starts
- 2015-09-22
- Expected to finish
- 2026-09-22
- Last updated by the study team
- 2023-10-24
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- BMI> 35 Eligible for bariatric surgery according to the current international guidelines (IFSO guidelines)
You may not qualify if…
- Patients affected by active liver viral infection
- Patient alcohol or drug addicted
- Incompetent patients
Where it is running
- Silvia Palmisano — Trieste, Italy (enrolling)
Full record on ClinicalTrials.gov
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