Adipose Tissue Blood Flow in Aging Humans

Recruiting now · Not applicable

Conditions studied: Healthy, Aging

In brief

The goal of this basic science clinical trial is to understand whether adipose tissue blood flow changes between younger and older healthy adults. The main question\[s\] it aims to answer are: * Is basal and nutrient responsive adipose tissue blood flow (ATBF) different between younger and older adults * What molecular and systemic signatures related to adipose tissue blood flow are altered between these two groups. Participants will undergo measurements of adipose tissue blood flow using the xenon washout technique, undergo 2 abdominal subcutaneous adipose tissue biopsies, and drink a sugary drink.

Key facts

Study ID

NCT06096532

Run by

Mayo Clinic

People needed

24

Starts

2024-02-15

Expected to finish

2028-12-30

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Within the ages of 18-35 years or 65-80 years at time of study visit
• BMI between 20-25.0 kg/m2.

You may not qualify if…

• Presence of diagnosed cardiometabolic diseases (e.g., Type 2 diabetes, hypertension, Heart Failure)
• Taking prescription anticoagulants
• Taking prescriptions or supplements that effect adipose tissue metabolism (i.e., statins, Thiazolidinediones, niacin, atypical antipsychotics, or fish oil)
• Pregnant or nursing
• Inability to provide written informed consent
• Smokers

Where it is running

• Mayo Clinic Minnesota — Rochester, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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