Cirrhotic Cardiomyopathy Based on Point-of-care Echocardiography, Biomarkers and Histology

Recruiting now

Conditions studied: Cirrhotic Cardiomyopathy, Cirrhosis, Liver, Cardiac Disease

In brief

Cirrhotic cardiomyopathy is associated with increased risk of complications like hepatorenal syndrome, refractory ascites, impaired response to stressors including sepsis, bleeding or transplantation, poor health related quality of life and increased morbidity and mortality. Left ventricular diastolic dysfunction (LVDD) is associated with risk of hepatorenal syndrome (HRS) , septic shock. , heart failure in the perioperative period following liver transplantation, and after trans-jugular intrahepatic portosystemic shunt (TIPS) insertion . The echocardiographic E/e' ratio is a predictor of survival in LVDD, with multiple studies, including prospective data from our Centre.

Key facts

Study ID

NCT06095466

Run by

Post Graduate Institute of Medical Education and Research, Chandigarh

People needed

150

Starts

2023-07-15

Expected to finish

2026-10-15

Last updated by the study team

2023-10-23

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with cirrhosis who have been diagnosed by clinical, biochemical, histological (when available) criteria plus ultrasound imaging will be included if they meet the following:
• Age range of 18-65 years
• Cirrhosis with critical illness admitted to the Liver Intensive Care Unit

You may not qualify if…

• Age >65 years
• Chronic renal disease
• Pregnancy and peripartum cardiomyopathy
• Valvular heart disease
• Sick sinus syndrome/ Pacemaker
• Transjugular intrahepatic porto systemic shunt (TIPS) insertion
• Hepatocellular carcinoma
• Anemia Hb < 8gm/dl in females, and < 9 gm/dl in males at the time of assessment

Where it is running

• Dr. Madhumita Premkumar — Sector-12, Chandigarh, India (enrolling)

Full record on ClinicalTrials.gov

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