A Retrospective Analysis of Outcomes in Patients With Hepatorenal Syndrome at Methodist Dallas Medical Center
Recruiting now
Conditions studied: Hepatorenal Syndrome
In brief
Hepatorenal syndrome (HRS) is a common cause of acute kidney injury (AKI) in patients with liver disease \[1\]. Increased activity and presence of vasodilators such as nitric oxide in cirrhotic patients leads to vasodilation, especially in the splanchnic circulation, resulting in hemodynamic changes that precipitate renal injury \[1\]. Patients may present with elevated serum creatinine (Cr), benign urine sediment, and low urine sodium \[1\].
Key facts
- Study ID
- NCT06095440
- Run by
- Methodist Health System
- People needed
- 500
- Starts
- 2023-05-13
- Expected to finish
- 2027-05-13
- Last updated by the study team
- 2026-05-01
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- All patients >18 years old that were hospitalized between April 1st 2019 and April 1st 2023 who either presented with HRS-AKI or developed a diagnosis of HRS during the hospital course. HRS-AKI will be defined based on the ICA criteria, described below:
- Presence of cirrhosis, acute liver failure, or acute-on-chronic liver failure
- An increase in serum Cr of ≥0.3 mg/dL within 48 hours or ≥50% from baseline value and/or urinary output ≤0.5 mL/kg of body weight for ≥6 hours (requires use of a urinary catheter)
- No full or partial response for ≥2 days of diuretic withdrawal and volume expansion with albumin (dosed at 1 g/kg of body weight/day)
- Absence of shock
- No current or recent treatment with nephrotoxic drugs
- Absence of parenchymal renal disease
- Suggestion of renal vasoconstriction based on FENa <0.2%
You may not qualify if…
- 1. HRS-AKI patients <18 years of age 2. All patients hospitalized between April 1st 2019 and April 1st 2023 without a diagnosis of HRS-AKI.
Where it is running
- Liver Institute of Methodist Dallas Medical Center — Dallas, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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