CTV Delineation Based Solely on Geometric Expansion From GTV in Nasopharyngeal Carcinoma
Recruiting now · Phase 3
Conditions studied: Nasopharyngeal Carcinoma by AJCC V8 Stage
In brief
This is a randomized, phase III, prospective, multi-center trial in newly diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. The aim of this study is to evaluate the efficacy and safety of modified IMRT, of which CTV delineation was only based on geometric expansion from GTV.
Key facts
- Study ID
- NCT06095154
- Run by
- Fujian Cancer Hospital
- People needed
- 474
- Starts
- 2025-01-01
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2025-03-13
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Pathologic diagnosis (pathologically confirmed by nasopharyngeal biopsy) was nasopharyngeal carcinoma;
- No distant metastatic;
- Patients with baseline MRI date of nasopharynx and neck, and completed the first course of treatment in our hospital;
- Eastern Cooperative Oncology Group (ECOG) score of 0 or 1;
- Signing informed consent;
- Follow up regularly and comply with test requirements.
You may not qualify if…
- Disease progression during IMRT;
- Previous malignancy or other concomitant malignant diseases;
- The evaluation information of tumor efficacy can not be obtained;
- Receive blind treatment in other clinical research;
- Have or are suffering from other malignant tumors within 5 years (except non- melanoma skin cancer or pre-invasive cervical cancer);
- Serious complications, such as uncontrolled hypertension, coronary heart disease, diabetes, heart failure, etc;
- Active systemic infection;
- No or limited capacity for civil conduct;
- The patient has a physical or mental disorder, and the researcher considers that the patient is unable to fully or fully understand the possible complications of this study;
- Pregnancy or lactation period;
Where it is running
- Fujian Cancer hospital — Fuzhou, Fujian, China (enrolling)
Full record on ClinicalTrials.gov
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