Study on Efficacy and Safety of Givinostat Versus Hydroxyurea in Patients With Polycythemia Vera

Recruiting now · Phase 3

Conditions studied: Polycythemia Vera

In brief

The goal of this clinical trial is to compare the efficacy and safety of givinostat to hydroxyurea in Jak2V617F-positive high risk polycythemia vera patients.

Key facts

Study ID

NCT06093672

Run by

Italfarmaco

People needed

220

Starts

2024-03-26

Expected to finish

2026-07-01

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Emad Ibrahim, MD, Inc — Redlands, California, United States (enrolling)
• CHU de Nice — Nice, Alpes-Maritimes, France (enrolling)
• American Oncology Partners of Maryland, PA — Bethesda, Maryland, United States (enrolling)
• Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)
• Centre Hospitalier de Saint-Quentin — Saint-Quentin, Aisne, France (enrolling)
• The Cleveland Clinic Foundation — Cleveland, Ohio, United States (enrolling)
• Oncology Associates of Oregon, P.C. — Eugene, Oregon, United States (enrolling)
• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Texas Oncology (Webster) - USOR — Houston, Texas, United States (enrolling)
• Texas Oncology-Denison Cancer Center — Sherman, Texas, United States (enrolling)
• US Oncology Inc — Englewood, Colorado, United States (enrolling)
• The James Cancer Hospital and Solove Research Institute — Roanoke, Virginia, United States (enrolling)
• VA Puget Sound Health Care System - NAVREF - PPDS — Seattle, Washington, United States (enrolling)
• Landesklinikum Wiener Neustadt — Wiener Neustadt, Lower Austria, Austria (enrolling)
• Medizinische Universitat Wien (Medical University of Vienna) — Vienna, State of Vienna, Austria (enrolling)
• Ordensklinikum Linz GmbH Elisabethinen — Linz, Upper Austria, Austria (enrolling)
• Klinikum Wels-Grieskirchen GmbH — Wels, Upper Austria, Austria (enrolling)
• Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda — Sofia, Sofia-Grad, Bulgaria (enrolling)
• University Multiprofile Hospital for Active Treatment Sveti Georgi EAD — Plovdiv, Bulgaria (enrolling)
• University Multiprofile Hospital for Active Treatment - Prof. Dr. Stoyan Kirkovich AD — Stara Zagora, Bulgaria (enrolling)
• Clinical Hospital Dubrava — Zagreb, City of Zagreb, Croatia (enrolling)
• Clinical Hospital Center Rijeka - PPDS — Rijeka, Croatia (enrolling)
• University of Utah - Huntsman Cancer Institute - PPDS — Salt Lake City, Utah, United States (enrolling)
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States (enrolling)
• Centre Hospitalier de Troyes — Troyes, Aube, France (enrolling)

Full record on ClinicalTrials.gov

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