Effect and Mechanism of Brain Stimulation for Parkinson's Disease With Cognitive Impairment

Recruiting now

Conditions studied: Parkinson Disease, Cognitive Impairment

In brief

This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.

Key facts

Study ID

NCT06090682

Run by

Tianjin Huanhu Hospital

People needed

200

Starts

2023-11-01

Expected to finish

2027-11-01

Last updated by the study team

2023-10-19

Who can join

Age: any, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.

You may not qualify if…

• Exclusion criteria included patients with severe cognitive impairment, severe psychiatric disorders, acute levodopa motor response less than 30%, atypical parkinsonism, and contraindications to surgery.

Where it is running

• Tianjin Huanhu Hospital — Tianjin, Tianjin Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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