Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

Recruiting now · Not applicable

Conditions studied: Liver Transplant

In brief

The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.

Key facts

Study ID

NCT06088758

Run by

Massachusetts General Hospital

People needed

200

Starts

2024-02-28

Expected to finish

2027-07-31

Last updated by the study team

2025-11-03

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-80 years
• Listed for liver transplantation at MGH
• Calculated MELD-Na score <= 25
• Able to consent

You may not qualify if…

• Status 1a
• Cardiac or pulmonary disease
• Prior liver transplant
• Requiring pressors at the time of liver offer
• MELD<15 and asymptomatic from liver disease

Where it is running

• Massachusetts General Brigham — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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