A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 52 Weeks of Treatment

Completed · Phase 3 · Has a placebo group

Conditions studied: Plaque Psoriasis

In brief

The main aim of this study is to show how well TAK-279 reduces the skin plaques compared to placebo, in participants with moderate-to-severe plaque psoriasis. Participants will be assigned to one of the 3 study treatments (TAK-279, apremilast (an approved treatment), or a placebo). Participants will be in the study for up to 61 weeks.

Key facts

Study ID

NCT06088043

Run by

Takeda

People needed

693

Starts

2023-11-06

Expected to finish

2025-10-22

Last updated by the study team

2025-10-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Plaque psoriasis for at least 6 months.
• Moderate to severe disease.
• Candidate for phototherapy or systemic therapy.

You may not qualify if…

• Other forms of psoriasis.
• History of recent infection.
• Prior exposure to TAK-279 or active comparator.
• Other protocol defined inclusion/exclusion criteria apply.

Where it is running

• SimcoDerm Medical and Surgical Dermatology Centre - Probity - PPDS — Barrie, Ontario, Canada
• Saguaro Dermatology Associates, LLC - Probity - PPDS — Phoenix, Arizona, United States
• First OC Dermatology - Fountain Valley — Fountain Valley, California, United States
• Center for Dermatology Clinical Research — Fremont, California, United States
• UCLA University of California Los Angeles — Los Angeles, California, United States
• UC Davis Dermatology Clinic — Sacramento, California, United States
• Driven Research LLC — Coral Gables, Florida, United States
• FXM Clinical Research Ft. Lauderdale, LLC — Fort Lauderdale, Florida, United States
• Direct Helpers Research Center — Hialeah, Florida, United States
• FXM Clinical Research Miami, LLC — Miami, Florida, United States
• Renstar Medical Research -21 NE 1st Ave — Ocala, Florida, United States
• Marietta Dermatology & The Skin Cancer Center - Marietta — Marietta, Georgia, United States
• Leavitt Clinical Research - 1542 Elk Creek Dr — Idaho Falls, Idaho, United States
• Arlington Dermatology — Rolling Meadows, Illinois, United States
• Dawes Fretzin Clinical Research Group-7910 N Shadeland Ave — Indianapolis, Indiana, United States
• Kindred Hair & Skin Center - CAR — Columbia, Maryland, United States
• Revival Research Corporation - Michigan - ClinEdge - PPDS — Troy, Michigan, United States
• Grekin Skin Institute — Warren, Michigan, United States
• Henderson Clinical Trials — Henderson, Nevada, United States
• Dartmouth Hitchcock Medical Center — Lebanon, New Hampshire, United States
• ALLCUTIS Research, LLC. — Portsmouth, New Hampshire, United States
• Northwell Health Physician Partners Dermatology at Lake Success - BRANY - PPDS — New York, New York, United States
• Accellacare of Cary — Cary, North Carolina, United States
• Bexley Dermatology Research - Probity - PPDS — Bexley, Ohio, United States
• CCA Medical Research - Probity - PPDS — Ajax, Ontario, Canada

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.